Publications:
- Sugawara, S., Kanamaru, Y., Sekine, S., Maekawa, L., Takahashi, A., Yamamoto, T., Watanabe, K., Fujisawa T., Hattori, K. and Ichijo, H.
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.
J. Biol. Chem., 295, 5588-5601 (2020).
- Homma, K., Takahashi, H., Tsuburaya, N., Naguro, I., Fujisawa T. and Ichijo, H.
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase.
J. Biol. Chem., 295, 3148-3158 (2020).
- Lambert JP†, Picaud S†, Fujisawa T., Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P*, Gingras AC* †These authors contributed equally to this work.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
Mol. Cell, 73, 1-18 (2019).
- Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T., and Ichijo, H.
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
Nat. Commun., 9, 2668 (2018).
- Fujisawa, T.*
Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors.
Adv. Biol. Regul., 66, 85-90 (2017).
* corresponding author
- Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka, S., Ohta, A., Tanaka, A., Watanabe, D., Morita, M., Takuma, H., Tamaoka, A., Kunath, T., Wray, S., Furuya, H., Era, T., Makioka, K., Okamoto, K., Fujisawa, T., Nishitoh, H., Homma, K., Ichijo, H., Julien, J.-P., Obata, N., Hosokawa, M., Akiyama, H., Kaneko, S., Ayaki, T., Ito, H., Kaji, R., Takahashi, R., Yamanaka, S. and Inoue, H.
iPSC-based drug repositioning identifies the Src/c-Abl pathway as a therapeutic target for ALS motor neurons.
Sci. Transl. Med., 9, pii: eaaf3962 (2017).
- Fujisawa, T., Filippakopoulos, P.
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.
Nat. Rev. Mol. Cell. Biol., 18, 246-262 (2017) [review article]
- Savitsky, P.†, Krojer, T.†, Fujisawa, T.†, Lambert, JP., Picaud, S., Wang, CY., Shanle, EK., Krajewski, K., Friedrichsen, H., Kanapin, A., Goding, C., Schapira, M., Samsonova, A., Strahl, BD., Gingras, AC., Filippakopoulos, P.
Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin
Cell Rep., 17, 2724-2737 (2016).
†These authors contributed equally to this work.
- Picaud, S., Leonards, K., Lambert, JP., Dovey, O., Wells, C., Fedorov, O., Monteiro, O., Fujisawa, T., Wang, CY., Lingard, H., Tallant, C., Nikbin, N., Guetzoyan, L., Ingham, R., Ley, SV., Brennan, P., Muller, S., Samsonova, A., Gingras, AC., Schwaller, J., Vassiliou, G., Knapp, S., Filippakopoulos, P.
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
Sci. Adv., 2, e1600760 (2016).
- Fujisawa T., Takahashi, M., Tsukamoto, Y., Yamaguchi, N., Nakoji, M., Endo, M., Kodaira, H., Hayashi, Y., Nishitoh, H., Naguro, I., Homma, K. and Ichijo, H.
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.
Hum. Mol. Genet., 25, 245-253 (2016).
- Fujisawa, T., Yamaguchi, N., Kadowaki, H., Tsukamoto, Y., Tsuburaya, N., Tsubota, A., Takahashi, H., Naguro, I., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Homma, K. and Ichijo, H.
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.
Neurobiol. Dis., 82, 478-486 (2015).
- Homma, K., Fujisawa, T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
Mol. Cell, 52, 75-86 (2013).
- Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann. Neurol., 72, 739-749 (2012).
- Fujisawa, T., Takeda, K. and Ichijo, H.
ASK family proteins in
stress response and disease.
Mol. Biotechnol., (review article), 37, 13-18 (2007).
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