Song, S., Kim, S.Y., Hong, Y.M., Jo, D.G., Lee, J.Y., Shim, S.M., Chung, C.W., Seo, S.J., Yoo, Y.J., Koh, J.Y., Lee, M.C., Yates, A.J., Ichijo, H. and Jung, Y.K.
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.
Mol. Cell, 12, 553-563 (2003).

  Huang, H., Shj, L., Dilling, M.B, Easton, J., Harwood, F.C., Ichijo, H. and Houghton, P.J.
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/ p21Cip1.
Mol. Cell, 11, 1491-1501 (2003).

  Cho, S.-G., Kim, J.W., Lee, Y.H., Hwang, H.S., Kim, M.-S., Ryoo, K., Kim, M.J., Noh K.T., Kim, E.K. Cho, J.-H., Yoon, K.W., Cho, E.-G., Park, H.-S., Chi, S.W., Lee, M.-J., Kang, S.S., Ichijo, H. , and Choi, E.-J.
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities.
J. Cell Biol., 163, 71-81 (2003).

  Oberst, A., Baehrecke, E., Mehmet, H., Ichijo, H. and Gupta, S.
A place to die for: apoptosis in cancer and infection, Capri 2002.
Cell Death Differ., 10, 393-395 (2003).

  Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H. and Iwao, H.
Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II-Induced Cardiac Hypertrophy and Remodeling.
Circulation Res., 93, 874-883 (2003).

  Izumi, Y., Kim, S., Yoshiyama, M., Izumiya, Y., Yoshida, K., Matsuzawa, A., Koyama, H., Nishizawa, Y., Ichijo, H., Yoshikawa, J. and Iwao, H.
Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia.
Circulation, 108, 2812-2818 (2003).

  Hashimoto, Y., Niikura, T., Chiba, T., Tsukamoto, E., Kadowaki, H., Nishitoh, H., Yamaguchi, Y., Ishizaka, M., Yamada, M., Nawa, M., Terashita, K., Aiso, S., Ichijo, H. and Nishimoto, I.
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained ASK1/JNK mediated neurotoxic signal via dimerization.
J. Pharmacol. Exp. Ther., 306, 889-902 (2003).

  Maruoka, S., Hashimoto, S., Gon, Y., Nishitoh, H., Takeshita, I., Asai, Y., Mizumura, K., Shimizu, K., Ichijo, H. and Horie, T.
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Biochem. Biophys. Res. Commun., 307, 870-876 (2003).

  Machino, T., Hashimoto, S., Maruoka, S., Gon, Y., Hayashi, S., Nishitoh, H., Ichijo, H. and Horie, T.
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide -induced apoptosis in human pulmonary vascular endothelial cells.
Crit. Care Med., 31, 2776-2781 (2003).

  Galvan, V., Logvinova, A., Sperandio, S., Ichijo, H. and Bredesen, D.E.
Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
J. Biol. Chem., 278, 13325-13332 (2003).

  Yamaguchi, O., Higuchi, Y., Hirotani, S., Kashiwase, K., Nakayama, H., Hikoso, S., Takeda, T., Watanabe, T., Asahi, M., Taniike, M., Matsumura, Y., Tsujimoto, I., Hongo, K., Kusakari, Y., Kurihara, S., Nishida, K., Ichijo, H., Hori, M. and Otsu, K.
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proc. Natl. Acad. Sci. USA., 100, 15883-15888 (2003).

  Yamagishi, S., Yamada, M., Koshimizu, H., Takai, S., Hatanaka, H., Takeda, K., Ichijo, H., Shimoke, K. and Ikeuchi, T.
Apoptosis-Signal Regulating Kinase-1 Is Involved in the Low Potassium-Induced Activation of p38 Mitogen-Activated Protein Kinase and c-Jun in Cultured Cerebellar Granule Neurons
J. Biochem., 133, 719-724 (2003).

  Takamatsu, H., Nagao, T., Ichijo, H. and Adachi-Akahane, S.
L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes.
J. Physiol., 552, 415-424 (2003).

  Matsukawa, J., Nakayama, K., Nagao, T., Ichijo, H. and Urushidani, T.
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
J. Biol. Chem., 278, 36470-36475 (2003).

  Tashiro,K., Nagao, T., Kurose, H., Ichijo, H. and Urushidani,  T. Role of Rho in Rabbit Parietal Cell.
J. Cell. Physiol., 197, 409-417 (2003).

  Yamaguchi, S., Zhorov, B.S., Yoshioka, K., Nagao, T., Ichijo, H., and Adachi-Akahane, S.
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel a1C subunit (CaV1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Mol. Phamracol. 64, 235-248 (2003).

Review articles

  Takeda, K., Matsuzawa, A., Nishitoh, H. and Ichijo, H.   Roles of MAPKKK ASK1 in Stress-Induced Cell Death.
Cell Struct Funct., (review article), 28, 23-29 (2003).

  Matsuzawa, A., Nishitoh, H., Takeda, K. and Ichijo, H.
MAP Kinases in Redox Signaling in "Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles" ed. by Forman HJ., Fukuto, J. and Torres, M., Kluwer Academic (review article), 223-236 (2003).