Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H.
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nat. Commun., 3, 1285 (2012).

  Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H.
The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Mol. Cell, 48, 692-704 (2012).

  Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann. Neurol., 72, 739-749 (2012).

  Sekine,S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
J. Biol. Chem., 287, 34635-34645 (2012).

  Lin, F.R., Huang, S.Y., Hung, K.H., Su, S.T., Chung, C.H., Matsuzawa, A., Hsiao, M., Ichijo, H. and Lin, K.I.
ASK1 promotes apoptosis of normal and malignant plasma cells.
Blood, 120, 1039-1047 (2012).

  Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R.,  Takeda, K., Ichijo, H., Maeda1, S. and Koike, K.
Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
Cancer Sci.,103, 2181-2185 (2012).

  Nako, H., Kataoka, K., Koibuchi, N., Dong, Y.F., Toyama, K., Yamamoto, E., Yasuda, O., Ichijo, H., Ogawa, H. and Mitsuyama, S.H.
Novel mechanism of angiotensin II-induced cardiacinjury in hypertensive rats: the critical role of ASK1.
Hypertens. Res., 35, 194-200 (2012).

  Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K.
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
PloS ONE, 7: e30265 (2012).

  Lee, K.W., Zhao, X., Im, J.Y., Grosso, H., Jang, W.H., Chan, T.W., Sonsalla, P.K., German, D.C.,  Ichijo, H., Junn, E., and Mouradian, M.M.
Apoptosis Signal-regulating Kinase 1 mediates MPTP toxicity and regulates glial activation.
PloS ONE, 7: e29935 (2012).

  Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K. and Tschopp, J.
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.
Cell Death & Disease, 3:e261 (2012).

Review articles

  Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H. Therapeutic targets in the ASK1-dependent stress signalling pathways.
Proc. Jpn. Acad. Ser. B: Phys. Biol. Sci., (review article), 88, 434-453 (2012).

  Kanamaru, Y., Sekine S., Ichijo, H. and Takeda, K.
The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses.
J. Signal Transduct., (review article), 2012, 12 (2012).

  Soga, M., Matsuzawa, A., Ichijo, H.
Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway.
Int. J. Cell Biol., (review article), 2012, 439587 (2012).