2001年

　 Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H. and Ichijo, H.
Negative feedback regulation of ASK1 by protein phophatase 5 (PP5) in response to oxidative stress.
EMBO J., 20, 6028-6036 (2001).　

　 Matsuzawa, A. and Ichijo, H.
Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1.
J. Biochem., 130, 1-8 (2001).

　 Arvidsson,Y., Hamazaki, T.S., Ichijo,H. and Funa, K.
ASK1 resistant neuroblastoma is deficient in activation of p38 kinase.
Cell Death and Differ., 8, 1029-1037 (2001).

　 Maeda, H., Hori, S., Nishitoh, H., Ichijo, H., Ogawa, O., Kakehi, Y., and Kakizuka, A.
Tumor growth inhibition by arsenic trioxide in the orthotopic metastasis model of androgen-independent prostate cancer.
Cancer Res., 61, 5432-5440 (2001).

　 Zou, X., Tsutsui, T., Ray, D., Blomquist, J.F., Ichijo, H., Ucker, D.S. and Kiyokawa, H.
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1 (ASK1).
Mol. Cell. Biol., 21, 4818-4828 (2001).

　 Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. and Greene W.C.
HIV-1 nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell.
Nature, 410, 834-838 (2001).

　 Sayama, K., Hanakawa, Y., Shirakata, Y., Yamasaki, K., Sawada, Y., Sun, L., Yamanishi, K., Ichijo, H. and Hashimoto, K.
Apoptosis signal regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
J. Biol. Chem., 276, 999-1004 (2001).

　 Sawada, Y., Nakamura, K., Doi, K., Takeda, K., Tobiume, K., Saitoh, M., Morita, K., Komuro, I., Kurt De Vos, Sheetz, M. and Ichijo, H.
Rap1 is Involved in Cell Stretching Modulation of p38 but not ERK or JNK MAP Kinase.
J. Cell Sci. 114, 1221-1227 (2001).

　 Noguchi, K., Kokubu, A., Kitanaka, C., Ichijo, H. and Kuchino, Y.
ASK1-Signaling Promotes c-Myc Protein Stability during Apoptosis.
Biochem. Biophys. Res. Commun., 281, 1313-1320 (2001).

　 Cho, S.-G., Lee, Y., Park, H.-S., Ryoo, K., Kang, K., Park, J., Eom, S.-J., Kim, M., Chang, T.-S., Choi, S.-Y., Shim, J., Kim, Y., Dong, M.-S., Lee, M.-J., Kim, S., Ichijo, H. and Choi, E.-J.
Glutathione s-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1 (ASK1).
J. Biol. Chem., 276, 12749-12755 (2001).

　 Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T. and Ichijo, H.
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
EMBO reports, 2, 222-228 (2001).

　 Hatai, T., Yokozeki, M., Funato, N., Baba, Y., Moriyama, K., Ichijo, H. and Kuroda, T.
Apoptosis of periodontal ligament cells induced by mechanical stress during tooth movement.
Oral Diseases, 7, 287-290 (2001).

　 Yanagisawa, M., Nakashima, K., Takeda, K., Ochiai, W., Takizawa, T., Ueno, M., Takizawa, M., Shibuya, H. and Taga, T.
Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.
Genes Cells, 6, 1091-1099 (2001).

2000年

　 Takeda, K., Hatai, T., Hamazaki, S., Nishitoh, H., Saitoh, M. and Ichijo H.
Apoptosis Signal- regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells.
J. Biol. Chem., 275, 9805-9813 (2000).

　 Liu, H., Nishitoh, H., Ichijo, H. and Kyriakis, J.M.
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor- associated factor 2 (TRAF2) requires prior dissociation of the ASK1 inhibitor Thioredoxin.
Mol. Cell. Biol., 20, 2198-2208 (2000).

　 Kanamoto, T., Mota, M., Takeda, K., Rubin, L.L., Miyazono, K., Ichijo, H. and Bazenet, C.E.
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal Kinase pathway and apoptosis in sympathetic neurons.
Mol. Cell. Biol., 20, 196-204 (2000).

　 Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H. and Takeda, K.
Execution of ASK1-induced Apoptosis by the Mitochondria-dependent Caspase Activation.
J. Biol. Chem., 275, 26576-26581 (2000).

　 Cai, Y., Zhang, C., Nawa T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H. and Kitajima, S.
Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2 terminal kinase and promoter response element.
Blood, 96, 2140-2148 (2000).

　 Mochida, Y., Takeda, K., Saitoh, M., Nishitoh, H., Amagasa, T., Ninomiya-Tsuji, j., Matsumoto, K. and Ichijo, H.
ASK1 inhibits IL-1-induced NF-kB activity through disruption of TRAF6-TAK1 interaction.
J. Biol. Chem., 275, 32747-32752 (2000).

1999年

　 Ichijo, H.
From receptors to stress-activated MAP kinases.
Oncogene (review article), 18, 6087-6093 (1999).

　 Yamamoto, K., Ichijo, H. and Korsmeyer, S.J.
BCL-2 is phosphorylated and inactivated by an ASK1/JNK pathway normally activated at G2/M.
Mol. Cell Biol., 19, 8469-8478 (1999).

　 Yasuda, S., Inoue, K., Hirabayashi, M., Higashiyama, H., Yamamoto, Y., Fuyuhiro, H., Komure, O., Tanaka, F., Sobue, G., Tsuchiya, K., Hamada, K., Sasaki, H., Takeda, K., Ichijo, H. and Kakizuka, A.
Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies.
Genes Cells, 4, 743-756 (1999).

　 Nakahara, S., Yone, K., Sakou, T., Wada, S., Nagamine, T., Niiyama, T. and Ichijo, H.
Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis.
J. Neuropathol. Exp. Neurol., 58, 442-450 (1999).

　 Chen, Z., Seimiya, H., Naito, M., Mashima, T., Kizaki, A., Dan, S., Imaizumi, M., Ichijo, H., Miyazono, K. and Tsuruo, T.
ASK1 mediates apoptotic cell death induced by genotoxic stress.
Oncogene, 18, 173-180 (1999).

　 Wang,T.H., Popp,D.M., Wang,H.S., Saitoh, M., Mural, J.G., Henley, D.C., Ichijo, H. and Wimalasena,J.
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells.
J. Biol. Chem., 274, 8208-8216 (1999).

　 Asada, M., Yamada, T., Ichijo, H., Delia, D., Miyazono, K., Fukumuro, K. and Mizutani, S.
Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation.
EMBO J., 18, 1223-1234 (1999).

　 Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T.K., Enomoto, S., Kawabata M., Kato, M., Ichijo, H. and Miyazono, K.
Roles of bone morphogenetic protein type I receptors and smad proteins in osteoblast and chondroblast differentiation.
Mol. Biol. Cell, 10, 3801-3813 (1999).

1998年

　 Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K. and Ichijo, H.
ASK1 is essential for JNK/SAPK activation by TRAF2.
Mol. Cell, 2, 389-395 (1998).

　 Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono K. and Ichijo, H.
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
EMBO J., 17, 2596-2606 (1998).

　 Chang, HY., Nishitoh, H., Yang, X., Ichijo, H. and Baltimore, D.
 Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein daxx.
Science, 281, 1860-1863 (1998).

　 Berestetskaya, Y.V., Faure, M.P., Ichijo, H., Tatyana, A. and Yasenetskaya, V.
Regulation of apoptosis by alhpa subunits of G12 and G13 proteins via apoptosis signal-regulating.
J. Biol. Chem., 273, 27816-27823 (1998).

　 Takeda, K., Ichijo, H., Fujii, M., Mochida, Y., Saitoh, M., Nishitoh, H., Sampath, T.K. and Miyazono, K.
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
J. Biol. Chem., 273, 17079-17085 (1998).

　 Wang, T.-H., Wang, H.-S., Ichijo, H., Giannakakou, P., Foster, J.S., Fojo, T. and Wimalasena, J.
Microtuble-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through both ras and apoptosis signal-regulating kinase (ASK1) pathways.
J. Biol. Chem., 273, 4928-4936 (1998).

　 Takase, M, Imamura, T., Sampath, T.K., Takeda, K., Ichijo, H., Miyazono, K. and Kawabata, M.
Induction of Smad6 mRNA by Bone Morphogenetic Proteins.
Biochem. Biophys. Res. Commun., 244, 26-29 (1998).

　 Saitoh, M., ten Dijke, P., Miyazono, K. and Ichijo, H.
Cloning and characterization of p70S6Kb defines a novel family of p70 S6 kinases.
Biochem. Biophys. Res. Commun., 253, 470-476 (1998).

　 Funato, N., Moriyama, K., Saitoh, M., Baba, Y., Ichijo, H. and Kuroda, T.
Evidence for apoptosis signal-regulating kinase (ASK)1 in the regenerating palatal epithelium upon acute injury.
Lab. Invest., 78, 477-483 (1998).

1997年

　 Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K. and Gotoh, Y.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science, 275, 90-94 (1997).

　 Yamashita, H., Shimizu, A., Kato, M., Nishitoh, H., Ichijo, H., Hanyu, A., Morita, I., Kimura, M., Makishima, F. and Miyazono, K.
Growth/differentiation factor-5 induces angiogenesis in vivo.
Exp. Cell Res., 235, 218-226 (1997).

　 Olofsson,A., Hellman,U., ten Dijke,P., Grimsby,S., Ichijo,H., Moren,A., Miyazono,K. and Heldin,C.-H.
Latent transforming growth factor-β complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.>
Biochem. J., 324, 427-434 (1997)

　 Tobiume, K., Inage, T., Takeda, K., Enomoto, S., Miyazono, K. and Ichijo, H.
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase (ASK) 1.
Biochem. Biophys. Res. Commun., 239, 905-910 (1997).

1996年　

　 Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M. and Ichijo, H.
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-β.
J. Biol. Chem., 271, 2769-2775 (1996).

　 Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S. and Miyazono, K.
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
J. Biol. Chem., 271, 21345-21352 (1996).

　 Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H.L. Miyazono, K. and Kawabata, M.
Characterization of the interaction of FKBP12 with the transforming growth factor-β type I receptor in vivo.
J. Biol. Chem., 271, 21687-21690 (1996).

　 Harumiya, S., Takeda, K., Sugiura, T., Fukumoto, Y., Tachikawa, H., Miyazono, K., Fujimoto, D. and Ichijo, H.
Charactrization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.
J. Biochem., 120, 745-751 (1996).

　 Niinaka, Y., Oida, S-I., Ishisaki, A., Takeda, K., Iimura, T., Maruoka, Y., Momose, F., Negishi, A., Ichijo, H., Amagasa, T., Sasaki, S., Watanabe, H. and Raz, A.
Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells.
Int. J. Oncology, 9, 433-438 (1996).